山东省济宁市太白湖新区荷花路133号 科研楼3楼
教育和工作经历
2022.07-至今 济宁医学院精准医学研究院
2018.09-2022.06 中山大学 实验员/博士后
2018.11-2020.12 比利时鲁汶大学 联合培养博士后
2015.09-2018.07 中山大学 中山眼科中心 基础医学博士
2012.09-2015.07 山东中医药大学 眼科学 硕士研究生
2008.09-2012.07 山东中医药大学 眼视光学 学士
研究领域与方向
主要研究增殖性玻璃体视网膜病变发生与发展的分子机制；
眼底新生血管及代谢研究
荣誉、奖励及主要社会兼职
1. 2015年度山东医学科技奖 二等奖 （6/6）
基金资助
1. 济宁医学院高层次人才科研启动基金（2023.04-2028.04）
代表性论文
1. Du Yuxiang, Yan Bo*. Ocular immune privilege and retinal pigment epithelial cells. J Leukoc Biol. 2023;113(3):288-304.
2. Du Yuxiang, Chen Qishan, Huang Lijuan, Wang Shasha, Yin Xiangke, Zhou Linbin, Ye Zhimin, Ren Xiangrong, Cai Yu, Ding Xiaoyan, Ouyang Hong, Li Xuri *, Ju Rong *. VEGFR2 and VEGF-C Suppresses the Epithelial-Mesenchymal Transition Via YAP in Retinal Pigment Epithelial Cells. Curr Mol Med. 2018, 18(5): 273-286.
3. Du Yuxiang, Guo Dadong, Wu Quxin, Jing Shi, Liu Dongmei, Bi Hongsheng*. Protective effects of appropriate Zn(2+) levels against UVB radiation-induced damage in human lens epithelial cells in vitro. J Biol Inorg Chem. 2016, 21(2):213-26.
4. Du Yuxiang, Guo Dadong, Wu Qiuxin, Liu Dongmei, Bi Hongsheng*. Zinc chloride inhibits human lens epithelial cell migration and proliferation involved in TGF-β1 and TNF-α signaling pathways in HLE B-3 cells. Biol Trace Elem Res. 159(1-3):425-433.
5. Joanna Kalucka#, Laura P.M.H. de Rooij#, Jermaine Goveia#, Katerina Rohlenova, Se´bastien J. Dumas, Elda Meta, Nadine V. Conchinha, Federico Taverna, Laure-Anne Teuwen, Koen Veys, Melissa Garcı´a-Caballero, Shawez Khan, Vincent Geldhof, Liliana Sokol, Rongyuan Chen, Lucas Treps, Mila Borri, Pauline de Zeeuw, Charlotte Dubois, Tobias K. Karakach, Kim D. Falkenberg, Magdalena Parys, Xiangke Yin, Stefan Vinckier, Yuxiang Du, Robert A. Fenton, Luc Schoonjans, Mieke Dewerchin, Guy Eelen, Bernard Thienpont, Lin Lin, Lars Bolund, Xuri Li*, Yonglun Luo*, Peter Carmeliet*. Single-Cell Transcriptome Atlas of Murine Endothelial Cells. Cell. 2020, 180(4): 764-779.
6. Pachiappan Arjunan#, Xianchai Lin#, Zhongshu Tang, Yuxiang Du, Anil Kumar, Lixian Liu, Xiangke Yin, Lijuan Huang, Wei Chen, Qishan Chen, Zhimin Ye, Shasha Wang, Haiqing Kuang, Linbin Zhou, Kai Xu, Xue Chen, Haitao Zeng, Weisi Lu, Yihai Cao, Yizhi Liu, Chen Zhao*, Xuri Li*. VEGF-B is a potent antioxidant. Proc Natl Acad Sci U S A. 2018, 115(41):10351-10356.
7. Xin Jia#, Chen Zhao#, Qishan Chen, Yuxiang Du, Lijuan Huang, Zhimin Ye, Xiangrong Ren, Shasha Wang, Chunsik Lee, Zhongshu Tang, Xuri Li*, Rong Ju*. JAM-C maintains VEGR2 expression to promote retinal pigment epithelium cell survival under oxidative stress. Thromb Haemost. 2017, 117(4):750-757.
8. Yida Jiang#, Xianchai Lin#, Zhongshu Tang, Chunsik Lee, Geng Tian, Yuxiang Du, Xiangke Yin, Xiangrong Ren, Lijuan Huang, Zhimin Ye, Wei Chen, Fan Zhang, Jia Mi, Zhiqin Gao, Shasha Wang, Qishan Chen, Liying Xing, Bin Wang, Yihai Cao, William C. Sessa*, Rong Ju*, Yizhi Liu*, Xuri Li*. Critical role of Caveolin-1 in ocular neovascularization and multitargeted antiangiogenic effect of Cavtratin via JNK. Proc Natl Acad Sci U S A. 2017, 114(40):10737-10742.
9. Ling Wang, Fang Sha, DaDong Guo, Hong-Sheng Bi*, JunKang Si, YuXiang Du, Kai Tang. Efficacy and economic analysis of Ex-PRESS implantation versus trabeculectomy in uncontrolled glaucoma: a systematic review and meta-analysis. Int J Ophthalmol. 2016, 9(1):124-31.
10. Lei Zheng#, Chen Zhao#, Yuxiang Du, Xianchai Lin, Yida Jiang, Chunsik Lee, Geng Tian, Jia Mi, Xianglin Li, Qishan Chen, Zhimin Ye, Lijuan Huang, Shasha Wang, Xiangrong Ren, Liying Xing, Wei Chen, Delong Huang, Zhiqin Gao, Shuping Zhang, Weisi Lu, Zhongshu Tang, Bin Wang*, Rong Ju*, Xuri Li*. PDGF-CC underlies resistance to VEGF-A inhibition and combinatorial targeting of both suppresses pathological angiogenesis more efficiently. Oncotarget. 2016, 7(47):77902-77915.
11. Dadong Guo, Peiming Gu, Zhengfeng Liu, Kai Tang, Yuxiang Du, Hongsheng Bi*. Proteomic analysis rat plasma with experimental autoimmune uveitis based on label-free liquid chromatography-tandem mass spectrometry (LC-MS/MS). Journal of Chromatography B, 2015, 976-977: 84-90.
12. Kai Tang#, JunKang Si#, DaDong Guo, Yan Cui, YuXiang Du, XueMei Pan, HongSheng Bi*. Ranibizumab alone or in combination with photodynamic therapy vs photodynamic therapy for polypoidal choroidal vasculopathy: a systematic review and meta-analysis. Int J Ophthalmol, 2015, 8(5):1056-66.
13. Guo Dadong, Du Yuxiang, Wu Qiuxin, Jiang Wenjun, Bi Hongsheng*. Disrupted calcium homeostasis is involved in elevated zinc ion-induced photoreceptor cell death. Arch Biochem Biophys. 2014, 560: 44-51.
14. Qiuxin Wu#, Dadong Guo#, Yuxiang Du, Dongmei Liu, Daoguang Wang and Hongsheng Bi*. UVB Irradiation Enhances TiO2 Nanoparticle-induced Disruption of Calcium Homeostasis in Human Lens Epithelial Cells. Photochem Photobiol. 2014, 90: 1324-1331.
15. JunKang Si#, Kai Tang#, HongSheng Bi, Da-Dong Guo, Jun-Guo Guo, YuXiang Du, Yan Cui, Xue-Mei Pan, Ying Wen, XingRong Wang*. Combination of ranibizumab with photodynamic therapy vs ranibizumab monotherapy in the treatment of age-related macular degeneration: a systematic review and meta-analysis of randomized controlled trials. Int J Ophthalmol. 2014, 7(3): 541-549.
16. Daoguang Wang#, Dadong Guo#, Hongsheng Bi*, Qiuxin Wua, Qingmei Tian, Yuxiang Du. Zinc oxide nanoparticles inhibit Ca2+-ATPase expression in human lens epithelial cells under UVB irradiation. Toxicol In Vitro. 2013, 27(8): 2117-2126.
17. Qiuxin Wu, Dadong Guo, Hongsheng Bi*, Daoguang Wang, Yuxiang Du. UVB irradiation-induced dysregulation of plasma membrane calcium ATPase1 and intracellular calcium homeostasis in human lens epithelial cells. Mol Cell Biochem. 2013, 382(1-2): 263-272.
18. 杜宇翔, 郭大东, 唐凯, 司俊康, 沙芳, 吴秋欣, 毕宏生*. 氯化锌对体外培养人晶状体上皮细胞HLE B-3生长的影响. 中华实验眼科杂志, 2015, 33(4): 306-310
19. 杜宇翔，郭大东，司俊康，唐凯，毕宏生*.贝伐单抗和雷珠单抗治疗渗出型老年性黄斑变性有效性meta分析. 中华眼底病杂志,2014,30（3）：304-307
20. 杜宇翔，郭大东，唐凯，司俊康，沙芳，毕宏生*.氯化锌对紫外线损伤的人晶状体上皮细胞的保护作用. 眼科新进展,2014,34(5):405-409
21. 杜宇翔，郭大东，毕宏生*.视觉系统中钙库操纵钙内流通路的研究进展. 眼科新进展，2014,34(4):389-393
22. 唐凯，司俊康，杜宇翔，吴建峰，周蒙蒙，毕宏生*. Toric硬性透气性角膜接触镜对33例高度散光眼的视力矫正作用．眼科新进展, 2014, 34(10): 937-939
23. 司俊康，郭俊国，唐凯，杜宇翔，郭大东，王兴荣*. 黄芪多糖对过氧化氢诱导大鼠视网膜神经节细胞氧化损伤的保护作用. 中国中医眼科杂志2014, 24(4): 235-239
24. 司俊康，郭俊国，毕宏生，唐凯，杜宇翔，郭大东，王兴荣*. 芪明颗粒治疗糖尿病视网膜病变系统评价. 中国实用眼科杂志，2014, 32(9): 1125-1129
25. 司俊康，郭俊国，郭大东，唐凯，杜宇翔，王兴荣*.黄芪多糖对过氧化氢诱导人视网膜色素上皮细胞氧化损伤的保护作用.眼科新进展，2015, 35(1): 18-21
26. 唐凯, 郭大东, 张莲, 司俊康, 杜宇翔, 毕宏生*. 龙胆泻肝汤对大鼠实验性自身免疫性葡萄膜炎的治疗作用. 眼科新进展，2015, 35(4):305-309
