山东省济宁市太白湖新区荷花路133号 科研楼3楼
baichunyu001@126.com/chunyu_bai@hotmail.com
教育和工作经历
2016.09-至今 济宁医学院精准医学研究院/山东大学齐鲁医学院硕士生导师
2014.09- 2016.07 中国农业科学院 博士后/助理研究员
2011.09- 2014.07 东北林业大学/中国农业科学院联合培养取得博士学位
2010.08- 2011.08 中国农业科学院 科研助理/研究实习员
研究领域与方向
(1)胰岛β细胞的凋亡途径(2)细胞外囊泡在T1DM早期诊断中的应用(3)干细胞及其细胞外囊泡在疾病治疗中的应用
荣誉、奖励及主要社会兼职
1. 中国动物遗传标记学会 理事、副秘书长
2. 国际胞外囊泡协会(ISEV) 会员
3. 中国老年学会精准医疗分会 会员
4. 中国农业科学院优秀博士后(2016)
基金资助
1. 国家自然科学基金面上项目:外泌体miR-212/132促进胰腺导管上皮细胞转分化为β细胞及其治疗TIDM(2020.01-2024.12)
2. 山东省自然科学基金重点项目 (2021.01-2024.12)
3. 山东省高校青创计划(2020.01-2022.12)
4. 国家自然科学基金青年基金项目(2017.01-2020.12)
5. 山东省自然科学基金博士基金项目(2017.07-2020.06)
6. 济宁医学院教师科研扶持基金(2017.01-2019.12)
7.济宁医学院高层次人才科研启动基金(2016.12-2021.12)
8. 中国博士后科学基金项目(2015.01– 2016.07)
代表性论文
1. Gao Y, Mi N, Wu W, Zhao Y, Fan F, Liao W, Ming Y, Guan W*, Bai C*. Transfer of inflammatory mitochondria via extracellular vesicles from M1 macrophages induces ferroptosis of pancreatic beta cells in acute pancreatitis. J Extracell Vesicles. 2024 Feb;13(2):e12410. 通讯作者,中科院一区,IF=16
2.Gao Y, Mi N, Zhang Y, Li X*, Guan W*, Bai C*. Uterine macrophages as treatment
targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-κB pathway. J Nanobiotechnology. 2022 Nov19;20(1):487. 通讯作者,中科院一区,IF=10.2
3. Shao Y, Wu W, Fan F, Liu H, Ming Y, Liao W, Bai C*, Gao Y*. Extracellular Vesicle Content Changes Induced by Melatonin Promote Functional Recovery of Pancreatic Beta Cells in Acute Pancreatitis. J Inflamm Res. 2023 Dec 27;16:6397-6413. 通讯作者
4. Yu Y, Li M, Zhao Y, Fan F, Wu W, Gao Y*, Bai C*. Immune cell-derived extracellular vesicular microRNAs induce pancreatic beta cell apoptosis. Heliyon. 2022 Dec 2;8(12):e11995. 通讯作者
5. Bai C, Zhang H, Zhang X, Yang W, Li X*, Gao Y*. MiR-15/16 mediate crosstalk between the MAPK and Wnt/β-catenin pathways during hepatocyte differentiation from amniotic epithelial cells. Biochim Biophys Acta Gene Regul Mech. 2019 May;1862(5):567-581.
6. Gao Y, Ma L, Bai C*, Zhang X, Yang W. Melatonin promotes self-renewal and nestin expression in neural stem cells from the retina. Histol Histopathol. 2019 Jun;34(6):645-654.
7. Gao Y, Zhang R, Wei G, Dai S, Zhang X, Yang W, Li X*, Bai C*. Long Non-coding RNA Maternally Expressed 3 Increases the Expression of Neuron-Specific Genes by Targeting miR-128-3p in All-Trans Retinoic Acid-Induced Neurogenic Differentiation From Amniotic Epithelial Cells. Front Cell Dev Biol. 2019 Dec 23;7:342.
8. Gao Y, Zhang R, Dai S, Zhang X, Li X*, Bai C*. Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation. Front Cell Dev Biol. 2019 Dec 20;7:351.
9. Bai C, Li X, Gao Y, Yuan Z, Hu P, Wang H, Liu C, Guan W*, Ma Y*. Melatonin improves reprogramming efficiency and proliferation of bovine-induced pluripotent stem cells. J Pineal Res. 2016 Sep;61(2):154-67.
10. Bai C, Li X, Gao Y, Wang K, Fan Y, Zhang S, Ma Y*, Guan W*. Role of microRNA-21 in the formation of insulin-producing cells from pancreatic progenitor cells. Biochim Biophys Acta. 2016 Feb;1859(2):280-93.
11. Bai C, Gao Y, Li X, Wang K, Xiong H, Shan Z, Zhang P, Wang W, Guan W*, Ma Y*. MicroRNAs can effectively induce formation of insulin-producing cells from mesenchymal stem cells. J Tissue Eng Regen Med. 2017 Dec;11(12):3457-3468.
12. Bai C, Gao Y, Li Q, Feng Y, Yu Y, Meng G, Zhang M*, Guan W*. Differentiation of chicken umbilical cord mesenchymal stem cells into beta-like pancreatic islet cells. Artif Cells Nanomed Biotechnol. 2015 Apr;43(2):106-11.
13. Bai C, Hou L, Zhang M, Wang L, Guan W* and Ma Y*. Identification and biological characterization of chicken embryonic cardiac progenitor cells. Cell Proliferation, 2013, 46, 232–242
14. Bai C, Hou L, Zhang M, Pu Y, Guan W*, Ma Y*. Characterization of vascular
endothelial progenitor cells from chicken bone marrow. BMC Vet Res. 2012 May 14;8:54.
15. Bai C, Li X, Hou L, Zhang M, Guan W*, Ma Y*. Biological characterization of chicken mesenchymal stem/progenitor cells from umbilical cord Wharton's jelly. Mol Cell Biochem. 2013 Apr;376(1-2):95-102.
16. Bai C, Chen S, Gao Y, Shan Z, Guan W*, Ma Y*. Multi-lineage potential research of bone marrow mesenchymal stem cells from Bama miniature pig. J Exp Zool B Mol Dev Evol. 2015 Dec;324(8):671-85.
17. Bai C, Hou L, Li F, He X, Zhang M*, Guan W*. Isolation and biological characteristics of beijing Fatty chicken skeletal muscle satellite cells. Cell Commun Adhes. 2012 Oct;19(5-6):69-77.
专利
1. 白春雨,高玉花. 一种胰岛β细胞体外制备方法. 国家发明专利. 授权专利号:201810561869.1
2. 白春雨,高玉花.生姜细胞外囊泡在制备用于促进毛囊干细胞增殖药物中的应用. 国家发明专利. 授权专利号:202211228624.X