连福明

时间:2021-03-28浏览:6790

连福明,博士,教授,院长助理

山东省济宁市太白湖新区荷花路133号 科研楼3

fmlian@mail.jnmc.edu.cn

教育和工作经历

2016.08 – 至今       济宁医学院精准医学研究院,硕士研究生导师

2013.05 – 2016.05  香港大学  李嘉诚医学院  博士后研究员 (Post-doctoral Fellow)

2007.09 – 2012.07  中国科学技术大学  生命科学学院  生物化学与分子生物学博士

2003.09 – 2007.07  青岛大学  医学院  生物技术学士

研究领域与方向

从事与疾病相关蛋白质的结构与功能研究,主要关注于参与肿瘤发生与耐药、氧化应激应答、DNA损伤应答等蛋白质的结构机制与药理学研究。主要研究方向:(1)重大疾病相关蛋白质的结构研究;(2)结构药理学研究。

荣誉、奖励及主要社会兼职

1.  济宁医学院自然科学二等奖

2.  Journal of Biomolecular Structure & Dynamics、Anti-Cancer Agents in Medicinal Chemistry、Protein & Peptide Letters等多种SCI期刊审稿人

基金资助

1.  国家自然科学基金面上项目32171260

2.  国家自然科学基金青年基金项目31700672

3.  山东省自然科学基金面上项目ZR2024MC165

代表性论文

1.    Lian, Fu-Ming*; Jiang, Yong-Liang; Yang, Wancai; Yang, Xiangwei*, Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle, International Journal of Biological Macromolecules, 2020, 161:1055-1060.

2.    Lian, Fu-Ming*; Yang, Xiangwei; Jiang, Yong-Liang; Yang, Feng; Li, Changlin; Yang, Wancai; Qian, Chengmin*. New structural insights into the recognition of undamaged splayed-arm DNA with a single pair of non-complementary nucleotides by human nucleotide excision repair protein XPA, International Journal of Biological Macromolecules, 2020, 148:466-474.

3.    Li, Changlin*; Sun, Hui; Wei, Wei; Liu, Qiuzi; Wang, Yinglei; Zhang, Ying; Lian, Fuming; Liu, Fangchao; Li, Chenchen; Ying, Kaicheng; Huo, Hang; Qi, Zhi; Li, Benyi*; Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression, Cellular Oncology,2020, 43(6):1099-1116.

4.    Lian, Fu-Ming*; Yang, Xiangwei; Yang, Wancai; Jiang, Yong-Liang; Qian, Chengmin*; Structural characterization of the redefined DNA-binding domain of human XPA, Biochemical and Biophysical Research Communications, 2019, 514(3):985-990.

5.    Lian, Fu-Ming*; Yang, Xiangwei; Yang, Wancai; Jiang, Yong-Liang; Qian, Chengmin*;  The redefined DNA-binding domain of human xeroderma pigmentosum complementation group A: production, crystallization and structure solution,  Acta Crystallographica Section F- Structural Biology Communications, 2019,75(Pt 1):62-66.

6.    Li, Tao; Wang,  Linsheng; Du, Yongming; Xie,  Si; Yang, Xi; Lian, Fuming; Zhou, Zhongjun*; Qian, Chengmin*; Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research, 2018, 46(6):3218-3231.

7.    Lian, Fu-Ming; Xie,  Si; Qian, Chengmin*; Crystal structure and SUMO binding of Slx1-Slx4 complex, Scientific Reports, 2016, 6:19331.

8.    Lian, Fu-Ming; Yu, Jiang; Ma, Xiao-Xiao; Yu, Xiao-Jie; Chen, Yuxing; Zhou, Cong-Zhao*; Structural snapshots of yeast alkyl hydroperoxide reductase Ahp1 peroxiredoxin reveal a novel two-cysteine mechanism of electron transfer to eliminate reactive oxygen species, Journal of Biological Chemistry, 2012, 287(21):17077-17087.