艾志营，博士，副教授
济宁医学院太白湖校区科研楼K309室
aizhiying@126.com
教育和工作经历
2016.08- 济宁医学院精准医学研究院教师
2013.08-2016.06 西北农林科技大学生命科学学院 细胞生物学博士
2010.08-2013.06 西北农林科技大学生命科学学院 生物化学与分子生物学专业硕士
2008.08-2010.07 青岛农业大学生命科学学院 生物科学专业本科
研究领域与方向
主要研究癌症发生发展转移的分子机制研究
荣誉、奖励及主要社会兼职
1. 中国细胞生物学会（CSCB）会员
基金资助
1. 国家自然科学基金青年基金项目1项：线粒体蛋白PYCR1调节结肠癌干细胞自我更新和分化的机制研究（2018.01-2020.12）
2. 济宁医学院博士科研启动基金（2017.01-2021.12）
代表性论文
1. Ai Z, Shao J, Shi X, Yu M, Wu Y, Du J, Zhang Y, Guo Z. Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901. Stem Cells Int. 2016; 2016:1792573.
2. Ai Z, Shao J, Wu Y, Yu M, Du J, Shi X, Shi X, Zhang Y, Guo Z. CHIR99021 enhances Klf4 Expression through β-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells. PLoS One.2016 Mar 3; 11(3):e0150936.
3. Zhang J, Gao Y, Yu M, Wu H, Ai Z, Wu Y, Liu H, Du J, Guo Z, Zhang Y. Retinoic Acid Induces Embryonic Stem Cell Differentiation by Altering Both Encoding RNA and microRNA Expression. PLoS One. 2015 Jul 10; 10(7):e0132566.
4. Wu Y, Liu F, Liu Y, Liu X, Ai Z, Guo Z, Zhang Y. GSK3 inhibitors CHIR99021 and 6-bromoindirubin-3'-oxime inhibit microRNA maturation in mouse embryonic stem cells. Sci Rep. 2015 Mar 2; 5:8666.
5. Gao Y, Han Z, Li Q, Wu Y, Shi X, Ai Z, Du J, Li W, Guo Z, Zhang Y. Vitamin C induces a pluripotent state in mouse embryonic stem cells by modulating microRNA expression. FEBS J. 2015Feb; 282(4):685-99.
6.Shi X, Yongyan Wu, Ai Z, Du J, Cao L, Guo Z, Zhang Y. MicroRNA modulation induced by AICA ribonucleotide in J1 mouse ES cells. PLoS One. 2014 Jul 31;9(7):e103724.
7. Du J, Wu Y, Ai Z, Shi X, Chen L, Guo Z. Mechanism of SB431542 in inhibiting mouse embryonic stem cell differentiation. Cell Signal. 2014 Oct;26(10):2107-16.
8. Du J, Wu Y, Liu Y, Ai Z, Wu H, ShiX, Guo Z, Zhang Y. E-cadherin is critical for SC1-induced colony growth of F9embryonic carcinoma cells. Cell Physiol Biochem. 2014;33(2):501-12.
9. Wu Y, Ai Z, Yao K, Cao L, Du J, Shi X, Guo Z, Zhang Y. CHIR99021 promotes self-renewal of mouse embryonic stem cells by modulation of protein-encoding gene and long intergenic non-coding RNA expression. Exp Cell Res. 2013 Oct 15; 319(17):2684-99.
10.Shi X, Wu Y, Ai Z, Liu X, Yang L, Du J, ShaoJ, Guo Z, Zhang Y. AICAR sustains J1 mouse embryonic stem cell self-renewal and pluripotency by regulating transcription factor and epigenetic modulator expression. Cell Physiol Biochem.2013;32(2):459-75.
11. Wu H, Wu Y, Ai Z, Yang L, Gao Y, Du J, Guo Z, Zhang Y. Vitamin C enhances Nanog expression via activation of the JAK/STAT signaling pathway. Stem Cells. 2014 Jan; 32(1):166-76.
12. Gao Y, Yang L, Chen L, Wang X, Wu H, Ai Z, Du J, Liu Y, Shi X, Wu Y, Guo Z, Zhang Y. Vitamin C facilitates pluripotent stem cell maintenance by promoting pluripotency gene transcription. Biochimie. 2013 Nov; 95(11):2107-13.
13. Li WZ, Ai ZY, Wang ZW, Chen LL, Guo ZK, Zhang Y. GATA-1 directly regulates Nanog in mouse embryonic stem cells. Biochem Biophys Res Commun. 2015 Sep 25;465(3):575-9.
14. Wei,Q., Liu, H., Ai, Z., Wu, Y., Liu, Y., Shi, Z., Ren, X., and Guo, Z. (2017). SC1 Promotes MiR124-3p Expression to Maintain the Self-Renewal of Mouse Embryonic Stem Cells by Inhibiting the MEK/ERK Pathway. Cellular physiology and biochemistry: international journal of experimental cellular physiology, biochemistry, and pharmacology 44, 2057-2072. 2366.
