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The Intestinal Microbiota in Colorectal Cancer.
来源:Cancer Cell. 2018 Mar 19. pii: S1535-6108(18)30072-2.    作者:Tilg H, Adolph TE, Gerner RR, Moschen AR   发布时间:2018/5/9 15:00:39

    Experimental evidence from the past years highlights a key role for the intestinal microbiota in inflammatory and malignant gastrointestinal diseases. Diet exhibits a strong impact on microbial composition and provides risk for developing colorectal carcinoma (CRC). Large metagenomic studies in human CRC associated microbiome signatures with the colorectal adenoma-carcinoma sequence, suggesting a fundamental role of the intestinal microbiota in the evolution of gastrointestinal malignancy. Basic science established a critical function for the intestinal microbiota in promoting tumorigenesis. Further studies are needed to decipher the mechanisms of tumor promotion and microbial co-evolution in CRC, which may be exploited therapeutically in the future.

 

 doi: 10.1016/j.ccell.2018.03.004. 

 

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