山东省济宁市太白湖新区荷花路133号 科研楼3楼
ysy843549261@126.com
教育和工作经历
2018.02-至今 济宁医学院精准医学研究院
2012.09- 2017.06 中国科学院微生物研究所 生物化学与分子生物学博士
研究领域与方向
主要从事细胞自噬及程序性细胞死亡的分子机制研究，及从肿瘤细胞代谢改变出发，探究肿瘤针对性及个性化治疗，降低耐药及副作用策略。
基金资助
1. 国家自然科学基金青年基金项目：PFKFB3和Wnt/β-catenin互作调控细胞自噬促进结肠癌的作用及机制（2019.01-2021.12）
2. 济宁医学院博士启动基金（2018.02-2023.02）
代表性论文
1. Zhang F, Li Q, Zhang Y, Li N, Rao M, Li S, Ai Z, Yan S*, Tian Z*. COPS3 inhibition promotes cell proliferation blockage and anoikis via regulating PFKFB3 in osteosarcoma cancer cells. Eur J Pharmacol, 2023, 175799
2. Yan S*, Li Q, Li S, Ai Z, Yuan D. The role of PFKFB3 in maintaining colorectal cancer cell proliferation and stemness. Mol Biol Rep, 2022, 49(10):9877-9891.
3. Yan S*, Li Q, Zhang D, Wang X, Xu Y, Zhang C, Guo D, Bao Y. Necroptosis pathway blockage attenuates PFKFB3 inhibitor-induced cell viability loss and genome instability in colorectal cancer cells. Am J Cancer Res, 2021, 11(5):2062-2080.
4. Yan S*, Yuan D, Li Q, Li S, Zhang F*. AICAR enhances the cytotoxicity of PFKFB3 inhibitor in an AMPK signaling-independent manner in colorectal cancer cells. Med Oncol, 2021, 39(1):10.
5. Yan S*, Zhou N, Zhang D, Zhang K, Wei W, Bao Y, Yang W*. PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells. INT J MOL SCI. 2019; 20(21):5415.
6. Yan S, Liu L, Ren F, Gao Q, Xu S, Hou B, Wang Y, Jiang X, Che Y*. Sunitinib induces genomic instability of renal carcinoma cells through affecting the interaction of LC3-II and PARP-1. CELL DEATH DIS. 2017; 8(8): e2988.
7. Yan S, Wei X, Xu S, Sun H, Wang W, Liu L, Jiang X, Zhang Y* and Che Y.* 6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase isoform 3 spatially mediates autophagy through the AMPK signaling pathway. Oncotarget. 2017; 8(46): 80909-80922.
8. Lu Q, Yan S, Sun H, Wang W, Li Y, Yang X, Jiang X, Che Y* and Xi Z.* Akt inhibition attenuates rasfonin-induced autophagy and apoptosis through the glycolytic pathway in renal cancer cells. CELL DEATH DIS. 2015; 6(12):e2005.
9. Yan S, Yang X, Chen T, Xi Z* and Jiang X.* The PPARγ agonist Troglitazone induces autophagy, apoptosis and necroptosis in bladder cancer cells. Cancer Gene Ther. 2014; 21: 188–193.
