山东省济宁市太白湖新区荷花路133号 科研楼3楼
shenwenzhi2011@126.com
教育和工作经历
2017.09-至今 济宁医学院精准医学研究院
2014.09- 2017.07 南开大学医学院 生物化学与分子生物学专业博士
2011.09- 2014.07 南开大学医学院 生理学专业硕士
2007.07-2011.09 潍坊医学院药学与生物科学学院 生物技术学士
研究领域与方向
主要致力于肿瘤干细胞及肿瘤微环境的研究，包括肿瘤干细胞、肿瘤炎症及肿瘤微环境、肿瘤免疫调节等，涉及的科学问题内容主要有1）肿瘤炎症与肿瘤干细胞；2）结直肠炎癌转化；3）肿瘤微环境细胞相互作用。
荣誉、奖励及主要社会兼职
1. 美国癌症研究协会（AACR）会员
2. BBRC、Cancer control、Oncotargets and Therapy、Journal of International Medical Research杂志审稿人
基金资助
1. 国家自然科学基金面上项目：ICAM3调控肿瘤相关巨噬细胞M2型极化促进结直肠癌进展功能及机制的研究（2022.01-2025.12）
2. 国家自然科学基金青年基金项目：ICAM3通过Src/PI3K/AKT 通路促进结直肠炎癌进展作用及机制的研究（2019.01-2021.12）
3. 山东省自然科学基金博士基金项目（2019.07-2022.06）
4. 山东省医药卫生项目面上项目（2017.12-2020.12）
5. 济宁医学院教师科研扶持基金（2019.01-2021.12）
6. 济宁医学院博士科研启动基金（2017.09-2022.09）
代表性论文
1．Shen W*, Zhang X, Tang J, Zhang Z, Du R, Luo D, Liu X, Xia Y, Li Y, Wang S, Yan S, Yang W, Xiang R, Luo N, Luo Y, Li J. CCL16 maintains stem cell-like properties in breast cancer by activating CCR2/GSK3β/β-catenin/OCT4 axis. Theranostics, 2021, 11(5): 2297-317.
2．Zhang X, Du R, Luo N, Xiang R, Shen W*. Aspirin mediates histone methylation that inhibits inflammation-related stemness gene expression to diminish cancer stemness via COX-independent manner. Stem Cell Res Ther, 2020, 11(1): 370.
3．Shen W*, Zhang X, Du R, Gao W, Wang J, Bao Y, Yang W, Luo N*, Li J*. Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner. Br J Cancer, 2020, 123(5): 730-41.
4．Luo D, Liu D, Shi W, Jiang H, Liu W, Zhang X, Bao Y, Yang W, Wang X, Zhang C, Wang H, Yuan L, Chen Y, Qu T, Ou D, Shen W*, Yang S*. PPA1 promotes NSCLC progression via a JNK- and TP53-dependent manner. Oncogenesis, 2019, 8(10): 53.
5．Zhao S#, Shen W#, Du R, Luo X, Yu J, Zhou W, Dong X, Gao R, Wang C, Yang H, Wang S*. Three inflammation-related genes could predict risk in prognosis and metastasis of patients with breast cancer. Cancer Med, 2019, 8(2): 593-605.
6．Luo D H, Zhang X Y, Du R L, Gao W J, Luo N, Zhao S T, Li Y, Chen R, Wang H, Bao Y H, Yang W C, Liu D S, Shen W Z*. Low dosage of arsenic trioxide (As2O3) inhibits angiogenesis in epithelial ovarian cancer without cell apoptosis. J Biol Inorg Chem, 2018, 23(6): 939-47.
7．Shen W, Zhang X, Du R, Fan Y, Luo D, Bao Y, Yang W, Luo N*, Luo Y*, Zhao S*. ICAM3 mediates tumor metastasis via a LFA-1-ICAM3-ERM dependent manner. Biochim Biophys Acta, 2018, 1864(8): 2566-78.
8．Zhao S#, Shen W#, Yu J, Wang L*. TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21-IL-4 pathway in lung adenocarcinoma. Stem Cell Res Ther, 2018, 9(1): 89.
9．Shen W, Xie J, Zhao S, Du R, Luo X, He H, Jiang S, Hao N, Chen C, Guo C, Liu Y, Chen Y, Sun P, Yang S, Luo N, Xiang R, Luo Y*. ICAM3 mediates inflammatory signaling to promote cancer cell stemness. Cancer Lett, 2018, 422(29-43).
10．Shen W, Du R, Li J, Luo X, Zhao S, Chang A, Zhou W, Gao R, Luo D, Wang J, Hao N, Liu Y, Chen Y, Luo Y, Sun P, Yang S, Luo N*, Xiang R*. TIFA suppresses hepatocellular carcinoma progression via MALT1-dependent and -independent signaling pathways. Signal Transduct Target Ther, 2016, 1(16013).
11．Shen W, Chang A, Wang J, Zhou W, Gao R, Li J, Xu Y, Luo X, Xiang R*, Luo N*, Stupack D G*. TIFA, an inflammatory signaling adaptor, is tumor suppressive for liver cancer. Oncogenesis, 2015, 4(e173).
12．Du R, Shen W, Liu Y, Gao W, Zhou W, Li J, Zhao S, Chen C, Chen Y, Liu Y, Sun P, Xiang R, Shi Y, Luo Y*. TGIF2 promotes the progression of lung adenocarcinoma by bridging EGFR/RAS/ERK signaling to cancer cell stemness. Signal Transduct Target Ther, 2019, 4(60).
13．Hao N, Shen W, Du R, Jiang S, Zhu J, Chen Y, Huang C, Shi Y, Xiang R, Luo Y*. Phosphodiesterase 3A represents a therapeutic target that drives stem cell-like property and metastasis in breast cancer. Mol Cancer Ther, 2020, 19(3): 868-81.
14．Huang Z, Zhou W, Li Y, Cao M, Wang T, Ma Y, Guo Q, Wang X, Zhang C, Zhang C, Shen W, Liu Y, Chen Y, Zheng J, Yang S, Fan Y*, Xiang R*. Novel hybrid molecule overcomes the limited response of solid tumours to HDAC inhibitors via suppressing JAK1-STAT3-BCL2 signalling. Theranostics, 2018, 8(18): 4995-5011.
15．Gao R, Li D, Xun J, Zhou W, Li J, Wang J, Liu C, Li X, Shen W, Qiao H, Stupack D G*, Luo N*. CD44ICD promotes breast cancer stemness via PFKFB4-mediated glucose metabolism. Theranostics, 2018, 8(22): 6248-62.
16．Gao R, Liu Y, Li D, Xun J, Zhou W, Wang P, Liu C, Li X, Shen W, Su W, Qiao H, Stupack D G*, Luo N*. PFKFB4 Promotes Breast Cancer Metastasis via Induction of Hyaluronan Production in a p38-Dependent Manner. Cell Physiol Biochem, 2018, 50(6): 2108-23.
