连福明，博士，副教授，院长助理
山东省济宁市太白湖新区荷花路133号 科研楼3楼
fmlian@mail.jnmc.edu.cn
教育和工作经历
2016.05 – 至今 济宁医学院精准医学研究院，硕士研究生导师
2013.05 – 2016.05 香港大学 李嘉诚医学院 博士后研究员 (Post-doctorial Fellow)
2007.09 – 2012.07 中国科学技术大学 生命科学学院 生物化学与分子生物学博士
2003.09 – 2007.07 青岛大学 医学院 生物技术学士
研究领域与方向
从事与疾病相关蛋白质的结构与功能研究，主要关注于参与肿瘤发生与耐药、氧化应激应答、DNA损伤应答等蛋白质的结构机制与药理学研究。主要研究方向：（1）重大疾病相关蛋白质的结构研究；（2）基于靶点结构的药物设计；（3）结构药理学研究
荣誉、奖励及主要社会兼职
1. 济宁医学院自然科学二等奖
2. 济宁医学院欧美同学会（留学人员联谊会）理事
3. Journal of Biomolecular Structure & Dynamics、Anti-Cancer Agents in Medicinal Chemistry、Protein & Peptide Letters等多种SCI期刊审稿人
基金资助
1. 国家自然科学基金面上项目：基于DTNB二硫键交联研究Prx5催化能力再生的分子结构机制（2022.01-2025.12）
2. 国家自然科学基金青年基金项目：XPA-RPA复合物参与核苷酸切除修复通路DNA损伤确认的关键组装机制研究（2018.01-2020.12）
代表性论文
1. Lian, Fu-Ming*; Jiang, Yong-Liang; Yang, Wancai; Yang, Xiangwei*, Crystal structure of sulfonic peroxiredoxin Ahp1 in complex with thioredoxin Trx2 mimics a conformational intermediate during the catalytic cycle, International Journal of Biological Macromolecules, 2020, 161:1055-1060.
2. Lian, Fu-Ming*; Yang, Xiangwei; Jiang, Yong-Liang; Yang, Feng; Li, Changlin; Yang, Wancai; Qian, Chengmin*. New structural insights into the recognition of undamaged splayed-arm DNA with a single pair of non-complementary nucleotides by human nucleotide excision repair protein XPA, International Journal of Biological Macromolecules, 2020, 148:466-474.
3. Li, Changlin*; Sun, Hui; Wei, Wei; Liu, Qiuzi; Wang, Yinglei; Zhang, Ying; Lian, Fuming; Liu, Fangchao; Li, Chenchen; Ying, Kaicheng; Huo, Hang; Qi, Zhi; Li, Benyi*; Mitoxantrone triggers immunogenic prostate cancer cell death via p53-dependent PERK expression, Cellular Oncology,2020, 43(6):1099-1116.
4. Lian, Fu-Ming*; Yang, Xiangwei; Yang, Wancai; Jiang, Yong-Liang; Qian, Chengmin*; Structural characterization of the redefined DNA-binding domain of human XPA, Biochemical and Biophysical Research Communications, 2019, 514(3):985-990.
5. Lian, Fu-Ming*; Yang, Xiangwei; Yang, Wancai; Jiang, Yong-Liang; Qian, Chengmin*; The redefined DNA-binding domain of human xeroderma pigmentosum complementation group A: production, crystallization and structure solution, Acta Crystallographica Section F- Structural Biology Communications, 2019,75(Pt 1):62-66.
6. Li, Tao; Wang, Linsheng; Du, Yongming; Xie, Si; Yang, Xi; Lian, Fuming; Zhou, Zhongjun*; Qian, Chengmin*; Structural and mechanistic insights into UHRF1-mediated DNMT1 activation in the maintenance DNA methylation, Nucleic Acids Research, 2018, 46(6):3218-3231.
7. Lian, Fu-Ming; Xie, Si; Qian, Chengmin*; Crystal structure and SUMO binding of Slx1-Slx4 complex, Scientific Reports, 2016, 6:19331.
8. Mu, Yinnan#; Lian, Fu-Ming#; Teng ,Yan-Bin; Ao, Jingqun; Jiang, Yong-Liang; He, Yong-Xing; Chen, Yuxing; Zhou, Cong-Zhao*; Chen, Xinhua*; The N-terminal beta-sheet of peroxiredoxin 4 in the large yellow croaker Pseudosciaena crocea is involved in its biological functions, PLoS One, 2013, 8(2):e57061.
9. Lian, Fu-Ming; Yu, Jiang; Ma, Xiao-Xiao; Yu, Xiao-Jie; Chen, Yuxing; Zhou, Cong-Zhao*; Structural snapshots of yeast alkyl hydroperoxide reductase Ahp1 peroxiredoxin reveal a novel two-cysteine mechanism of electron transfer to eliminate reactive oxygen species, Journal of Biological Chemistry, 2012, 287(21):17077-17087.
